Royal Air Force Typhoon jets have operated alongside French warplanes in a combined operation against an subterranean weapons facility in Syria used by the IS group, as stated by the UK Ministry of Defence.
The site, located using surveillance, was thought to be housing weapons and explosive materials, the statement said, and was situated in mountains just above Palmyra in Syria's central region.
"Our aircraft employed precision-guided Paveway IV munitions to hit a several entry passages providing entry to the depot... early reports are that the target was engaged successfully," the ministry announced.
There was no sign of any civilian impact in the operation late on Saturday and every plane involved returned to base without incident, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as the so-called Islamic State - imposed jihadist rule over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This action underscores British leadership, and determination to stand shoulder to shoulder with our partners, to stamp out any revival of the terrorist group and their dangerous and violent ideologies in the area," the British Defence Secretary the Defence Secretary stated.
RAF aircraft have carried out overwatch operations over Syrian airspace to "deter any attempted comeback" of Islamic State following its defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I want to thank the personnel of British forces participating in this mission for their expertise and their valour," he added. "They were among numerous British personnel deployed over Christmas and New Year. This action, to remove militants who endanger our way of life, highlights how our armed forces are always on standby, all year round, ensuring Britain's security domestically and powerful internationally."
During December, the American forces carried out what it called a "large-scale strike" targeting IS targets in the country, subsequent to an attack killed two US troops and a civilian linguist in Palmyra.
The UN reports IS still has an estimated 5,000 to 7,000 fighters in Syria and Iraq.